ABSTRACT
Analysis of T-lymphocytes and their subsets in the blood and bronchoalveolar lavage fluids from 12 patients with active pulmonary tuberculosis, 12 patients with bronchogenic carcinoma and 11 healthy volunteers was aimed at identifying their immunologic functions and interrelationships. In patients with active pulmonary tuberculosis, there was a significant increased in the percentage of T-cells bearing IL-2 receptor both in the blood and bronchoalveolar lavage fluids, whereas patients with bronchogenic carcinoma exhibited an increase in the suppressor T-cells and T-cells bearing IL-2 receptor in the blood only. The presence of T-cells bearing IL-2 receptor is generally accepted to be the hallmark of recently active specific antigen activation of the helper T-lymphocytes together with monokine IL-1 stimulation. Suppressor T-cells, on the other hand, play a role in the immunopathogenesis of lung cancers and lung metastasis.
Subject(s)
Adult , Aged , Bronchoalveolar Lavage Fluid/cytology , Carcinoma, Bronchogenic/analysis , Female , Humans , Lung Neoplasms/analysis , Male , Middle Aged , Receptors, Interleukin-2/analysis , T-Lymphocytes/analysis , Tuberculosis, Pulmonary/immunologyABSTRACT
Se revisan los principales aspectos relacionados con el diagnostico, clasificacion y tratamiento del cancer del pulmon. Infortunadamente, a pesar de los grandes avances obtenidos en el campo de la cirugia, la radioterapia y la quimioterapia, el pronostico de esta enfermedad continua siendo malo. La sobrevida global a 5 anos es menor del 10%. En consecuencia, el exito obtenido en el control de la enfermedad dependera basicamente de su prevencion y diagnostico temprano
Subject(s)
Humans , Male , Female , Carcinoma, Bronchogenic , Lung Neoplasms , Bronchoscopy , Carcinoma, Bronchogenic/analysis , Carcinoma, Bronchogenic/secondary , Lung Neoplasms/analysis , Lung Neoplasms/drug therapy , Lung Neoplasms/secondary , Lung Neoplasms/surgery , Lung Neoplasms/ultrastructure , Spirometry , Tomography, X-Ray ComputedABSTRACT
Partindo-se da aparência radiológica altamente sugestiva de exposiçäo ao asbesto (caso 1) ou de uma história ocupacional positiva (casos 2 e 3), envestigamos a presença de fibras em tecido pulmonar em blocos de autópsia ou biópsia cirúrgica de três casos de carcinoma broncogênico, pelo método de digestäo de tecido pulmonar em hipoclorito de sódio, seguido da observaçäo do resíduo através da microscopia óptica por contraste de fase. Nos três casos, a pesquisa de fibras foi positiva. A relaçäo das neoplasias a exposiçäo ao asbesto é altamente provável, pelo fato de dois dos casos apresentaram fibrose pulmonar (casos 1 e 2) e, o terceiro caso, placas pleurais perietais típicas a toracotomia